Question 11 pts
Bioavailability is affected by which of the following factors?
Group of answer choices
Drug’s dose
Patient’s age
Patient’s weight
Drug’s solubility
Patient’s gender
Question 21 pts
What is an indication for gemfibrozil?
Group of answer choices
Hepatitis
Sepsis
Hypertension
Gallstone pancreatitis
Hypertriglyceridemia
Question 31 pts
According to the Global Initiative for Chronic Obstructive Lung Disease (GOLD), what is the defining ratio of FEV1/FVC for confirmation of chronic obstructive pulmonary disease (COPD)?
Group of answer choices
Less than 0.70
Less than 0.75
A ratio of FEV1/FVC is not required for the confirmation of COPD.
Less than 0.80
Less than 0.85
Question 41 pts
A patient presents with severe COPD. She asks what her surgical options might include in the future. Which of the following is NOT a surgical treatment offered for this disease?
Group of answer choices
Lung volume reduction
Lung transplant
VATS procedure for treatment of a secondary pneumothorax
Bullae resection
Pulmonary catheterization
Question 51 pts
Warfarin exerts its anticoagulant effect through which of the following mechanisms?
Group of answer choices
Acting as a vasodilator
Inhibition of platelet activation
Activation of antithrombin 3
Inhibition of the production of the clotting factors II, VII, IX, X
Direct inhibition of factor Xa
Question 61 pts
A patient with a 2-year history of asthma, previously well controlled, presents for progressive worsening of symptoms in spite of good adherence to treatment with scheduled steroid inhalers. The patient has no exposure to pets and is not a smoker. Chest X-ray is unremarkable. What pathology should this patient be worked up for?
Group of answer choices
Pulmonary embolism
Bronchiectasis
Tuberculosis
Allergic bronchopulmonary aspergillosis
Pneumoconiosis
Question 71 pts
If a patient starts taking Drug A with a Kd of 100 nM (nanomolar) and then switches to Drug B with a Kd of 100 µM (micromolar), and both drugs target the same receptor, which of the following statements is true?
Group of answer choices
The toxicity of Drug A is much higher than the toxicity of Drug B.
The binding affinities of the two drugs are not different.
More people in a population will respond to Drug A than to Drug B.
Drug B has higher efficacy.
The binding affinity of Drug A is much higher than the binding affinity of Drug B.
Question 81 pts
Which statement about HMG-CoA reductase inhibitor toxicity is INCORRECT?
Group of answer choices
Cerivastatin was withdrawn from the market due to the risk of rhabdomyolysis.
They may increase creatine kinase levels.
The addition of ezetimibe to atorvastatin has a higher risk of rhabdomyolysis than the addition of gemfibrozil.
They may increase liver transaminases.
The effect of simvastatin may be reduced with the co-administration of CYP450 inducers.
Question 91 pts
Which two drugs are dihydropyridine calcium channel blockers?
Group of answer choices
Nifedipine and verapamil
Nifedipine and amlodipine
Verapamil and diltiazem
Felodipine and verapamil
Verapamil and amlodipine
Question 101 pts
What is a potential adverse effect of PCSK9 inhibitors?
Group of answer choices
Colon cancer
Hypoglycemia
Marked elevation of liver transaminases
Injection site reactions
Hypertriglyceridemia
Solution:
Question 11 pts
Bioavailability is affected by which of the following factors?
Group of answer choices
Drug’s dose
Patient’s age
Patient’s weight
Drug’s solubility
Patient’s gender
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