(Solution) NURS6521 week 3 quiz: Many versions available

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Version 1:

  1. Bioavailability is affected by which of the following factors?
  2. Drug’s dose
    b. Patient’s age
    c. Patient’s weight
    d. Drug’s solubility
    e. Patient’s gender
  3. A complete drug order includes which of the following?
  4. Drug
    b. Amount to dispense
    c. Number of refills
    d. Frequency
    e. Dose
  5. Which of the following drugs is a recombinant monoclonal antibody that specifically binds to free human immunoglobulin E (IgE) in the blood and interstitial fluid and removes it from the patient’s circulation so that mast cells do not get sensitized?
  6. Epinephrine
    b. Bevacizumab
    c. Zafirlukast
    d. Omalizumab
    e. Alemtuzumab
  7. What happens when you administer two highly bound protein medications at the same time?
  8. Both drugs have an increased amount of active drug available
    b. Both drugs have a decreased amount of active drug available
    c. The reaction is unpredictable
    d. The drugs will cancel the activity of each other
  9. Which statement about HMG-CoA reductase inhibitor toxicity is INCORRECT?
  10. Cerivastatin was withdrawn from the market due to the risk of rhabdomyolysis.
    b. They may increase creatine kinase levels.
    c. The addition of ezetimibe to atorvastatin has a higher risk of rhabdomyolysis than the addition of gemfibrozil.
    d. They may increase liver transaminases.
    e. The effect of simvastatin may be reduced with the co-administration of CYP450 inducers.
  11. What is a potential adverse effect of PCSK9 inhibitors?
  12. Colon cancer
    b. Hypoglycemia
    c. Marked elevation of liver transaminases
    d. Injection site reactions
    e. Hypertriglyceridemia
  13. If a patient starts taking Drug A with a Kd of 100 nM (nanomolar) and then switches to Drug B with a Kd of 100 µM (micromolar), and both drugs target the same receptor, which of the following statements is true?
  14. The toxicity of Drug A is much higher than the toxicity of Drug B.
    b. The binding affinities of the two drugs are not different.
    c. More people in a population will respond to Drug A than to Drug B.
    d. Drug B has higher efficacy.
    e. The binding affinity of Drug A is much higher than the binding affinity of Drug B.
  15. Which two drugs are dihydropyridine calcium channel blockers?
  16. Nifedipine and verapamil
    b. Nifedipine and amlodipine
    c. Verapamil and diltiazem
    d. Felodipine and verapamil
    e. Verapamil and amlodipine
  17. What is an indication for gemfibrozil?
  18. Hepatitis
    b. Sepsis
    c. Hypertension
    d. Gallstone pancreatitis
    e. Hypertriglyceridemia
  19. Which statement most accurately describes a drug with high efficacy and high potency?
  20. It requires a large dose to exert a significant effect.
    b. It requires only a small dose to exert a significant effect.
    c. The maximum dose does not cause a significant effect.
    d. Even a large dose will not cause a significant effect.
    e. No dose change will lead to a change in the clinical effect.

Version 2:

Question 11 pts

Bioavailability is affected by which of the following factors?

Group of answer choices

Drug’s dose

Patient’s age

Patient’s weight

Drug’s solubility

Patient’s gender

Question 21 pts

What is an indication for gemfibrozil?

Group of answer choices

Hepatitis

Sepsis

Hypertension

Gallstone pancreatitis

Hypertriglyceridemia

Question 31 pts

According to the Global Initiative for Chronic Obstructive Lung Disease (GOLD), what is the defining ratio of FEV1/FVC for confirmation of chronic obstructive pulmonary disease (COPD)?

Group of answer choices

Less than 0.70

Less than 0.75

A ratio of FEV1/FVC is not required for the confirmation of COPD.

Less than 0.80

Less than 0.85

Question 41 pts

A patient presents with severe COPD. She asks what her surgical options might include in the future. Which of the following is NOT a surgical treatment offered for this disease?

Group of answer choices

Lung volume reduction

Lung transplant

VATS procedure for treatment of a secondary pneumothorax

Bullae resection

Pulmonary catheterization

Question 51 pts

Warfarin exerts its anticoagulant effect through which of the following mechanisms?

Group of answer choices

Acting as a vasodilator

Inhibition of platelet activation

Activation of antithrombin 3

Inhibition of the production of the clotting factors II, VII, IX, X

Direct inhibition of factor Xa

Question 61 pts

A patient with a 2-year history of asthma, previously well controlled, presents for progressive worsening of symptoms in spite of good adherence to treatment with scheduled steroid inhalers. The patient has no exposure to pets and is not a smoker. Chest X-ray is unremarkable. What pathology should this patient be worked up for?

Group of answer choices

Pulmonary embolism

Bronchiectasis

Tuberculosis

Allergic bronchopulmonary aspergillosis

Pneumoconiosis

 

Question 71 pts

If a patient starts taking Drug A with a Kd of 100 nM (nanomolar) and then switches to Drug B with a Kd of 100 µM (micromolar), and both drugs target the same receptor, which of the following statements is true?

Group of answer choices

The toxicity of Drug A is much higher than the toxicity of Drug B.

The binding affinities of the two drugs are not different.

More people in a population will respond to Drug A than to Drug B.

Drug B has higher efficacy.

The binding affinity of Drug A is much higher than the binding affinity of Drug B.

Question 81 pts

Which statement about HMG-CoA reductase inhibitor toxicity is INCORRECT?

Group of answer choices

Cerivastatin was withdrawn from the market due to the risk of rhabdomyolysis.

They may increase creatine kinase levels.

The addition of ezetimibe to atorvastatin has a higher risk of rhabdomyolysis than the addition of gemfibrozil.

They may increase liver transaminases.

The effect of simvastatin may be reduced with the co-administration of CYP450 inducers.

Question 91 pts

Which two drugs are dihydropyridine calcium channel blockers?

Group of answer choices

Nifedipine and verapamil

Nifedipine and amlodipine

Verapamil and diltiazem

Felodipine and verapamil

Verapamil and amlodipine

 

Question 101 pts

What is a potential adverse effect of PCSK9 inhibitors?

Group of answer choices

Colon cancer

Hypoglycemia

Marked elevation of liver transaminases

Injection site reactions

Hypertriglyceridemia

 Solution:

  1. Which of the following drugs is a recombinant monoclonal antibody that specifically binds to free human immunoglobulin E (IgE) in the blood and interstitial fluid and removes it from the patient’s circulation so that mast cells do not get sensitized?
  2. Epinephrine
    b. Bevacizumab
    c. Zafirlukast
    d. Omalizumab (Correct Answer)
    e. Alemtuzumab
  3. What happens when you administer two highly bound protein medications at the same time?
  4. Both drugs have an increased amount of active drug available (Correct Answer)
    b. Both drugs have a decreased amount of active drug available
    c. The reaction is unpredictable
    d. The drugs will cancel the activity of each other

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